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Product Name: |
Rutin |
Synonyms: |
3,3’,4’,5,7-pentahydroxy-flavon3-(o-rhamnosylglucoside);3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,74H-1-Benzopyran-4-one;3-[[6-O-(-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;4-dihydroxyphenyl)-5,7-dihydroxy-yranosyl]oxy]-2-(;4h-1-benzopyran-4-one,3-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucop;bioflavonoid;globularicitrin;ilixathin |
CAS: |
153-18-4 |
MF: |
C27H30O16 |
MW: |
610.52 |
EINECS: |
205-814-1 |
Product Categories: |
reference substance;Aromatics;Heterocycles;Oligosaccharides;Plant extracts;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;ONGLYZA;Flavanols;Biochemistry;Disaccharides;Flavonoids;Glycosides;Sugars;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;TROXEPURE |
Mol File: |
153-18-4.mol |
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Rutin Chemical Properties |
Melting point |
195 °C (dec.)(lit.) |
alpha |
D23 +13.82° (ethanol); D23 -39.43° (pyridine) |
Boiling point |
576.13°C (rough estimate) |
density |
1.3881 (rough estimate) |
refractive index |
1.7650 (estimate) |
storage temp. |
Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
solubility |
pyridine: 50 mg/mL |
Colour Index |
75730 |
form |
powder |
color |
yellow to green |
Water Solubility |
12.5 g/100 mL |
Merck |
8304 |
CAS DataBase Reference |
153-18-4(CAS DataBase Reference) |
NIST Chemistry Reference |
Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4) |
EPA Substance Registry System |
4H-1-Benzopyran- 4-one, 3-[[6-O-(6-deoxy-.alpha.-L- mannopyranosyl)-.beta.-D- glucopyranosyl]oxy]-2-(3, 4-dihydroxyphenyl)-5,7-dihydroxy- (153-18-4) |
Hazard Codes |
Xn,Xi |
Risk Statements |
22-36/37/38 |
Safety Statements |
24/25-36-26 |
WGK Germany |
3 |
RTECS |
VM2975000 |
F |
8 |
Toxicity |
LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison) |
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Rutin Usage And Synthesis |
Chemical Properties |
Pale-Yellow Crystalline Solid |
Uses |
Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions. |
Uses |
antidiabetic, dipeptidyl peptidase–4 inhibitor |
Uses |
For nutritional product |
Uses |
rutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants. |
Definition |
ChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups. |
Purification Methods |
The vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.] |
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Rutin Preparation Products And Raw materials |