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Home > Products >  ACADESINE

ACADESINE CAS NO.2627-69-2

  • FOB Price: USD: 1.00-1.00 /Kilogram Get Latest Price
  • Min.Order: 1 Gram
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  • Available Specifications:

    98(1-5)Kilogram99(1-2)Kilogram

  • Product Details

Keywords

  • AICAR
  • EINECS:220-097-5
  • AICA-RIBOSIDE

Quick Details

  • ProName: ACADESINE
  • CasNo: 2627-69-2
  • Molecular Formula: C9H14N4O5
  • Appearance: powder
  • Application: glucose uptake stimulant; AMPK activat...
  • DeliveryTime: Within 3 days after payment
  • PackAge: as required
  • Port: Shanghai
  • ProductionCapacity: 10 Kilogram/Day
  • Purity: 98%
  • Storage: ask
  • Transportation: by air or by sea
  • LimitNum: 1 Gram
  • Molecular Weight:: 258.23
  • EINECS:: 220-097-5

Superiority

AICAR Basic information
adenosine regulating agents
Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File: 2627-69-2.mol
AICAR Structure
 
AICAR Chemical Properties
Melting point  214-215 °C
storage temp.  −20°C
solubility  H2O: >10 mg/mL
form  powder
color  tan
Water Solubility  Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax 265nm(NaOH)(lit.)
Merck  14,16
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference 2627-69-2(CAS DataBase Reference)
EPA Substance Registry System 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
 
Safety Information
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-45-53
WGK Germany  3
TSCA  Yes
MSDS Information
Provider Language
SigmaAldrich English
 
AICAR Usage And Synthesis
adenosine regulating agents Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). 
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties Solid
Uses glucose uptake stimulant; AMPK activator
Uses AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Coreychem focus on high complex new type intermediates and fine chemical custom synthesis,scale-up production and rare chemicals trade.Product category including Intermediates&API,Catalyst and Electronic Chemicals.Covering 811 square meters R&D center,with 45 person R&D team,our synthesis level is well-known to the industry,which are exported to France,Poland,Czech,Ukraine,Spain,Switzerland,etc...

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Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.
 
The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.
 
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1. Samples synthetic, Our strong r&d team has accumulated abundant experience in synthesis design and exploring synthesis of new technology. Not only good at heterocyclic chemistry, chiral chemicals (asymmetric synthesis and enzyme reaction), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry including nucleosides, nucleotides, sugar chemical, peptide chemistry, etc, to complete the synthesis from mg to kg samples in lab scale. Our efficient management and good communication skills and ability to solve the problem rapidly in order to ensure quality, timely delivery, based on the standard client confidential system and competitive price products,we has been recognized and praised by many customers in chemical industry.
       
2. Scale-up production, based on our rich laboratory experience and advanced equipment in production base, also depend on accumulation of advantages in many aspects as industrialized technology development, the production cost control, to provide from kg class to wt class custom synthesis scale-up production services to the global fine chemical industry, can be carried out oxidation, hydrogenation pressure (70 kg), halide, and acylation, esterification, condensation, cyclization, formatting, ammoniation, diazotization and azide reaction, our experienced production management, strict and perfect management system can quickly provide customers with competitive and fine mass production services.
  
3.Technology transfer, the company has accumulated a large number of production processes of drugs, intermediates and raw material. Based on the principle of mutual benefit, and some technology transfer to industry manufacturers, also provides them marketing support.
  
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